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The preclinical-to-clinical translation of this principle requires further validation, but the data are directionally consistent

Black box warnings highlight risks of medullary thyroid cancer and acute pancreatitis (incidence: 0.320.39%), 16 implying that before medication administration, patients must undergo strict screening to exclude those with a (family) history of medullary thyroid cancer, a history of pancreatitis, and high-risk conditions (such as biliary tract diseases or hyperlipidemia)

Al activar los receptores GLP-1, el medicamento estimula la secrecin de insulina de manera dependiente de glucosa, lo que significa que promueve la liberacin de insulina solo cuando los niveles de azcar en sangre estn elevados

It is important to note that these findings are not conclusive, and more research is needed to fully understand how semaglutide might impact the eyes, especially in people who are at risk of or already have glaucoma